In the end, Deadpool gains the upper hand in the fight and Francis admits that there is no cure for Wade's disfigurement. Deadpool and Francis then engage in a bloody hand-to-hand combat before Negasonic uses her power to destroy the aircraft carrier. Their intervention enables Francis to run off, and when Colossus handcuffs himself to Deadpool on their way back to the X-Mansion, Deadpool cuts off his own hand and escapes back to his home.The next night, Weasel convinces Deadpool to go back to Vanessa, but when they arrive at the strip club she works at, Deadpool discovers that she has been kidnapped, and Francis and Angel Dust tell him to meet up with them on a decommissioned aircraft carrier at a scrapyard.Deadpool convinces Colossus and Negasonic to help him, and the trio take a cab to the scrapyard, where Colossus and Negasonic have a grueling battle with Angel Dust while Deadpool slashes through an army of goons on his way toward Francis. The confrontation is suddenly interrupted by the X-Men Colossus and Negasonic Teenage Warhead, who want him to join the team.

Wade moves into the home of an elderly blind woman named Al, and with the advice of his best friend Weasel, he becomes a masked vigilante named 'Deadpool', and begins hunting down Francis and dismantling his organization.Following a string of leads from various syndicates, Deadpool attacks a convoy of cars on an expressway before getting his hands on Francis, demanding for a cure to his disfigurement. He is then impaled by rebar and left for dead in the destruction of the lab.Although he tracks her down, he cannot come to terms with his complexion, and he keeps himself away from Vanessa. He escapes from the chamber by blowing it up and attempts to kill Francis, only stopping when he claims he can cure Wade's disfigurement. The drop in oxygen triggers a healing factor that removes his cancer, but severely disfigures his face and skin in the process. After weeks of no success, Wade is strapped into an airtight chamber after insulting Francis. He is injected with a special serum by Francis Freeman and tortured for days by Angel Dust in order to trigger a mutation. Desperate to live, he reconsiders and leaves Vanessa in the middle of the night to undergo the procedure. Offered an experimental cure for his cancer, but he rebuffs the man and leaves.

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